Open AccessStudies on transcription of the yeast URA 2 gene
Author(s) -
Potier S.,
Lacroute F.,
Hubert J.C.,
Souciet J.L.
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb03891.x
Subject(s) - aspartate carbamoyltransferase , transcription (linguistics) , proofreading , pyrimidine metabolism , gene , yeast , uridine triphosphate , biochemistry , psychological repression , chemistry , enzyme , biology , gene expression , polymerase , escherichia coli , nucleotide , linguistics , purine , philosophy
The multifunctional protein carbamoylphosphate synthetase (CPSase)‐aspartate transcarbamylase (ATCase) encoded by the URA2 gene catalyses the first two steps of the yeast pyrimidine pathway. An excess of the final product, the intracellular UTP (uridine triphosphate), inhibits both the transcription of the URA2 gene and the enzymatic activities. Results presented in this paper suggest that transcription of URA2 is negatively regulated (repression‐depression) and establish that this regulation is less efficient in the flow of the pyrimidine pathway than feedback inhibition.