Open AccessHaemin inhibits the trypsin‐like enzyme activity of Porphyromonas gingivalis W83
Author(s) -
Fiona Sally U.,
Curtis Michael A.
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb03883.x
Subject(s) - porphyromonas gingivalis , trypsin , protease , enzyme , chemistry , bacteroidaceae , microbiology and biotechnology , biochemistry , metalloproteinase , biology , bacteria , genetics
The effect of haemin and related porphyrins on the activity of the trypsin‐like enzyme activity in cell sonicates of Porphyromonas gingivalils was examined wuing a spectrophotometric assay and by following the degradation of human IgG. Haemin was inhibitory in both assay systems and the effect was shown to be reversible. The high concentration of haemin accumulated by P. gingivalis may protect the organism against autodegradative effects of the trypsin‐like protease.