Open AccessRole of neuraminidase‐dependent adherence in Bacteroides fragilis attachment to human epithelial cells
Author(s) -
Guzmán C.A.,
Platé M.,
Pruzzo C.
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb03820.x
Subject(s) - bacteroides fragilis , neuraminidase , biology , cell , microbiology and biotechnology , receptor , bacterial adhesin , enzyme , biochemistry , gene , escherichia coli , antibiotics
Of 50 B. fragilis strains isolated from clinical samples we have demonstrated that 24 (48%) possess an adhesin that mediates a neuraminidase‐dependent attachment of B. fragilis to mammalian epithelial cells, but does not mediate any association with human polymorphonuclear leucocytes. This ligand interacts with a mammalian cell receptor that contains a galactoside residue, exposed after neuraminidase pretreatment. Our results suggest a possible role for cell associated neuraminidase in mediating a two step adherence mechanism.