Open AccessExperimental rat vaginal infection with Candida parapsilosis
Author(s) -
Bernardis Flavia,
Lorenzini Rodolfo,
Morelli Luisella,
Cassone Antonio
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb03611.x
Subject(s) - candida parapsilosis , vagina , vaginitis , microbiology and biotechnology , vaginal disease , corpus albicans , biology , candida albicans , estrogen , asymptomatic , ovariectomized rat , gynecology , medicine , endocrinology , anatomy
The experimental vaginopathic potential of Candida parapsilosis was determined in ovariectomized rats maintained under pseudoestrus by estrogen administrations. Of the 3 strains of C. parapsilosis tested, that isolated from the vagina of a woman affected by vulvovaginal candidosis gave a prolonged and sustained experimental vaginitis, not different in extent and duration from that caused by a vaginal isolate of C. albicans from a vaginitis patient. The other two isolates of C. parapsilosis (one from the vagina of an asymptomatic subject and another from soil) were unable to infect rat vagina. Microscopic observations PAS‐stained vaginal smears from rats infected with the vaginopathic isolate of C. parapsilosis showed pronounced adherence of yeasts to exfoliated cells. In addition, this isolate of C. parapsilosis produced an elevated quantity of acid proteinase in vitro.