Open AccessThe barrier function of the outer membrane of Pseudomonas maltophilia in the diffusion of saccharides and β‐lactam antibiotics
Author(s) -
Yamazaki Etsuko,
Ishii Junko,
Sato Kazuhito,
Nakae Taiji
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb03424.x
Subject(s) - microbiology and biotechnology , antibiotics , pseudomonas aeruginosa , bacterial outer membrane , chemistry , lactam , pseudomonas , diffusion , beta lactam , bacteria , biology , biochemistry , stereochemistry , escherichia coli , physics , genetics , gene , thermodynamics
This paper reports that the efficiency of solute diffusion throgh the outer membrane of Pseudomonas maltophilia is roughly 3 to 5% of that of Escherichia coli . This is despite the fact that the outer membrane pore(s) is only a little smaller than that of E. coli . These results suggest that P. maltophilia has a low copy number of porin(s). The outer membrane of antibiotic resistant clinical isolates showed even less efficient permeability towards saccharides and antibiotics than the laboratory strains.