Open AccessSAR‐2: Identification of a novel plasmid‐encoded β‐lactamase from India
Author(s) -
Sarada Nandivada L.,
Amyes S.G.B.
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb03302.x
Subject(s) - plasmid , identification (biology) , computational biology , biology , microbiology and biotechnology , genetics , gene , botany
A novel β‐lactamase has been identified in an Escherichia coli strain isolated in South India. The β‐lactamase gene was carried on a plasmid (pUK734) along with resistance determinants to sulphonamides and tetracycline. The novel enzyme has a pI of 8.3 and an M r of 36 000. The enzyme has a broad‐spectrum of activity against both penicillins and cephalosporins. It is also active against oxacillin and methicillin.