Open AccessSalmonella typhimurium infection in high and low antibody responder mice: inverse correlation between antibody responsiveness and resistance to infection
Author(s) -
Sant'Anna Osvaldo A.,
Massa Solange,
Mouton Denise,
Bouthillier Yolande,
Mevel JeanClaude,
Ibanez Olga M.,
Vassao Ruth,
Franco Marcelo,
Bellinati Raquel,
Siqueira Maria,
Biozzi Guido
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb02437.x
Subject(s) - salmonella , microbiology and biotechnology , biology , antibody , intracellular , salmonella infection , enterobacteriaceae , in vitro , bacteria , virology , immunology , escherichia coli , gene , genetics
Susceptibility to Salmonella typhimurium infection was compared in H (high Ab responder) and L (low Ab responder) mice obtained by several selective breeding experiments (Selections I, II, III, IV and IV A) [10,19,22]. H mice were always much more susceptible to infection than their L mice counterparts within a continuous LD 50 variation range. In three of the selections (I, II and IV A) the low responsiveness character is known to result mainly from rapid Ag degradation in L mice macrophages. It was hypothesized that resistance to multiplication of intracellular pathogens could be related to an increased catabolic activity towards Ag. This was actually demonstrated, in F 2 segregant hybrids of selection IV A, by the significant inverse correlation between capacity for Ab production and resistance to infection.