Open AccessSecretor state and renal scarring in girls with recurrent pyelonephritis
Author(s) -
Lomberg H.,
Hellström M.,
Jodal U.,
Svanborg Eden C.
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb02423.x
Subject(s) - scars , medicine , urinary system , chronic pyelonephritis , kidney , gastroenterology , dermatology , surgery
The non‐secretor phenotype was significantly associated with the occurrence of renal scarring among patients with recurrent pyelonephritis. Girls ( n = 77) with recurrent pyelonephritis were followed from the first known episode of infection for up to twelve years with repeated radiological investigations. They were divided into two categories: those with renal scars ( n = 35) and those who did not develop scars ( n = 42). There was a significant over‐representation of non‐secretors among the patients with scarring, (14/35, 40%) compared to the healthy controls (21.8%, P < 0.05). The frequency of non‐secretors among the girls who did not develop scars in spite of repeated episodes of acute pyelonephritis was not significantly different from the healthy controls (9/42, 21%, n.s.). This study provides a basis for analysis of the influence of secretor state on host‐parasite interaction in the urinary tract.