Open AccessSystemic spread of Campylobacter jejuni after intravenous infections
Author(s) -
Bär Werner,
Becker Konrad,
Hewel Claudia
Publication year - 1989
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1989.tb02391.x
Subject(s) - campylobacter jejuni , phagocytosis , microbiology and biotechnology , phagocyte , virulence , biology , macrophage , immunology , antibody , bacteria , in vitro , biochemistry , genetics , gene
Mice were infected intravenously with Campylobacter jejuni in order to study systemic translocation of this vibrio, as well as the interactions between bacteria and the host's defense mechanisms. It was found that granulocytes phagocyte C. jejuni in the bloodstream and that phagocytosis could be stimulated with LPS‐pretreatment or, less effectively, opsonizing antibodies. It could also be demonstrated that these circulating ‘infected’ granulocytes are eliminated from the bloodstream mostly by the hepatic Kupffer's cells and that virulent strains of C. jejuni persist in the liver up to thirty days. It has to be concluded that phagocytosis by granulocytes and clearance of C. jejuni from the bloodstream by the liver represent important defense mechanisms in systemic Campylobacter infections.