Open AccessPhospholipases as possible virulence factor in Vibrio parahaemolyticus
Author(s) -
Guhathakurta Bhakti,
Sasmal Dipti,
Datta Archana
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb13921.x
Subject(s) - vibrio parahaemolyticus , microbiology and biotechnology , phospholipase , hemolysin , virulence , clostridium perfringens , virulence factor , biology , phospholipase c , enzyme , vibrionaceae , vibrio infections , toxin , phospholipase a , phospholipase a1 , lecithinase , biochemistry , bacteria , phospholipase a2 , gene , genetics
Phospholipase C activity was elevated in pathogenic Vibrio parahaemolyticus isolated from patients. Phospholipase A activity was more pronounced in the nonpathogenic V. parahaemolyticus strains isolated from water. Extracts of the strains containing phospholipase C and A activity but no thermostable direct haemolysin (TDH) were capable of producing lesions in guinea pig skin indicating the presence of a toxic factor other than TDH. It is suggested that the toxic factor may be phospholipase C since the purified enzyme from Clostridium perfringens produced a similar reaction in guinea pig skin.