Open AccessExocellular products from Bifidobacterium adolescentis as immunomodifiers in the lymphoproliferative responses of mouse splenocytes
Author(s) -
Gómez E.,
Melgar M.M.,
Silva G.Pérez,
Portolés A.,
Gil I.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb03148.x
Subject(s) - lymphoproliferative response , splenocyte , chemistry , bifidobacterium , actinomycetaceae , microbiology and biotechnology , biochemistry , biology , immunology , in vitro , lactobacillus , peripheral blood mononuclear cell , fermentation
Extracts of exocellular products from Bifidobacterium adolescentis and their fractions were tested as immunomodifiers of the murine lymphoproliferative response. The extracts induced a dose dependent blastogenic activation which was higher for the fractions rich in polysacharides. When interacting with lectins, neither the extracts nor the protein‐rich fractions produced any effect on the lymphoproliferative response. The carbohydrate‐rich fractions stimulated DNA synthesis in LPS‐sensitive B lymphocytes but decreased it in Con A‐sensitive T lymphocytes.