Open AccessEffect of anti‐mycobacterial antibodies on activation of the alternative pathway of the human complement system
Author(s) -
Parkash Om.,
Ramanathan V.D.,
Singh D.P.,
Sengupta U.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02810.x
Subject(s) - antimycobacterial , heterologous , complement system , antibody , alternative complement pathway , microbiology and biotechnology , mycobacterium , complement (music) , chemistry , biology , classical complement pathway , mycobacterium tuberculosis , immunology , bacteria , biochemistry , tuberculosis , medicine , genetics , pathology , complementation , gene , phenotype
Mycobacterium vaccae and BCG showed activation (at the level of C3) of the alternative pathway of the human complement system as seen by enzyme linked immunosorbent assay (ELISA). Antimycobacterial antibodies were found to have enhancing effect on C3 uptake by these mycobacteria. The homologous antibodies showed more enhancing effect in comparison to heterologous antibodies.