Open AccessCharacterization of monoclonal lipid A antibodies with synthetic lipid A analogues
Author(s) -
Arata S.,
Mashimo J.,
Kasai N.,
Okuda K.,
Aihara Y.,
Kotani S.,
Takada H.,
Shiba T.,
Kusumoto S.,
Shimamoto T.,
Kusunose N.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02780.x
Subject(s) - epitope , monoclonal antibody , lipid a , chemistry , biochemistry , enzyme , antibody , salmonella , biology , bacteria , immunology , genetics
Abstract The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme‐linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.