Open AccessB‐lymphocyte mitogenicity and adjuvanticity of an ornithine‐containing lipid or a serine‐containing lipid
Author(s) -
Kawai Y.,
Kamoshita K.,
Akagawa K.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02705.x-i1
Subject(s) - chemistry , lipid a , splenocyte , serine , ornithine , pharmacology , biochemistry , lipopolysaccharide , immunology , in vitro , amino acid , arginine , biology , enzyme
An ornithine‐containing lipid (Orn‐L) or a serine‐containing lipid (Ser‐L) from Flavobacterium meningosepticum exhibited strong mitogenicity for the splenocytes from both LPS‐responder C3H/HeSlc and LPS‐low‐responder C3H/HeJ mice. The potency of the lipoamino acids was the same as that of LPS for responder mice. The lipoamino acids were B‐lymphocyte mitogens. Furthermore, Orn‐L or Ser‐L exhibited strong adjuvanticity. Compared with the adjuvanticity of LPS, the activity of Orn‐L was rather high. Based on these data, together with the previously reported data of macrophage activation, we propose that the lipoamino acids are non‐toxic, potent immunoactivators.