Open AccessRegulation of porin gene expression over a wide range of extracellular pH in Escherichia coli K‐12: Influence of a tolA mutation
Author(s) -
Heyde Martine,
Lazzaroni JeanClaude,
MagnoulouxBlanc Brigitte,
Portalier Raymond
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02572.x
Subject(s) - porin , mutant , extracellular , gene , transcriptional regulation , gene expression , biology , microbiology and biotechnology , chemistry , biochemistry , bacterial outer membrane , escherichia coli
Analysis of porin gene expression as a function of extracellular pH (pH o ) showed that ompF and lamB expression passed through a maximum, whereas ompC expression passed through a minimum at pH 8. This pH‐dependent control operated at both transcriptional and post‐transcriptional levels of ompF , but only at the transcriptional level on ompC . Similar studies carried out with tolA, tol B and excC mutant strains showed that the TolA, TolB and ExcC proteins are involved in the pH regulation of porin genes.