Open AccessThe effects of cultural conditions on growth and secondary metabolism in Streptomyces thermoviolaceus
Author(s) -
James P.D.A.,
Edwards C.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02562.x
Subject(s) - streptomyces , secondary metabolite , biomass (ecology) , proline , food science , secondary metabolism , metabolite , metabolism , fructose , xylan , carbon fibers , mesophile , carbon source , chemistry , biochemistry , biology , bacteria , biosynthesis , polysaccharide , agronomy , amino acid , enzyme , genetics , materials science , composite number , composite material , gene
Granaticin, an isochromate quinone antibiotic is synthesized as a secondary metabolite by Streptomyces thermoviolaceus . Antibiotic productivity was investigated under a variety of cultural conditions, including complex and defined media, mesophilic and thermophilic temperatures and a variety of sole carbon sources. In a defined medium growth was supported, to varying extents, by different carbon sources and in most cases granaticin production was observed. Highest biomass and granaticin yields were obtained when cultures were grown in the presence of xylan, fructose, glutamate or proline as carbon source. Changes in pH during growth affected both the timing and extent of granaticin production.