Open AccessInduction of tumour necrosis factor by staphylococcal toxic shock toxin 1
Author(s) -
Azavedo Joyce C.S.,
Drumm Annamarie,
Jupin Claude,
Parant Monique,
Alouf Joseph E.,
Arbuthnott John P.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02493.x
Subject(s) - tumor necrosis factor alpha , toxin , in vivo , toxic shock syndrome , necrosis , in vitro , microbiology and biotechnology , shock (circulatory) , immunology , biology , monocyte , staphylococcus aureus , chemistry , pharmacology , medicine , bacteria , biochemistry , genetics
Staphylococcal toxic shock syndrome toxin 1 (TSST1) induced the release of tumour necrosis factor (TNF) from human and rabbit monocytes in vitro. Nanogram amounts of TSST1 were sufficient to induce TNF release. There was considerable variation in response between cells from different rabbits and different donors. Rabbit monocytes were slightly more sensitive to TSST1 than were human monocytes. Release of TNF in vivo could explain many of the symptoms of toxic shock syndrome.