Open AccessOK‐432 and IL‐2‐augmental cytotoxicity of human natural killer cells and cytotoxic T lymphocytes at the clonal level
Author(s) -
Gravekamp Claudia,
Vreugdenhil Rea,
Bolhuis Reinder L.H.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02488.x
Subject(s) - cytotoxic t cell , cytotoxicity , phytohaemagglutinin , lytic cycle , natural killer cell , biology , cd3 , interleukin 2 , interleukin 12 , clone (java method) , microbiology and biotechnology , immunology , cd8 , lymphocyte , immune system , in vitro , biochemistry , gene , virus
The biology response modifiers OK‐432 and interleukin‐2 (IL‐2) were found to enhance the lytic capacity of cloned CD3 − natural killer (NK) cells and CD3 + T cells. With respect to NK cells, only those clones with a high proliferative capacity and cultured without phytohaemagglutinin (PHA) responded with enhaced lytic capacity to OK‐432. OK‐432, but not IL‐2, was found to augment the antibody‐dependent cellular cytotoxicity of cloned NK cells. With T‐cell clones, OK‐432 augmented the cellular cytotoxicity of CD3 + 8 + but not that of CD3 + 4 + cytotoxic T lymphocytes, while IL‐2 augmented the cytotoxicity of both types of clone. Taken together, these results indicate that OK‐432‐augmented lytic capacity is not restricted to NK cells and its pathway of action may be independent of IL‐2.