2,3‐Diamino‐2,3‐dideoxyuronic and 5,7‐diamino‐3,5,7,9‐tetradeoxynonulosonic acids: new components of bacterial polysaccharides

The discovery of the derivatives of 2,3‐diamino‐2,3‐dideoxyuronic acids and 5,7‐diamino‐3,5,7,9‐tetradeoxynonulosonic acids in bacterial polysaccharides enlarges the list of natural monosaccharides. Many of the new sugars carry unusual N ‐substituents, such as formyl, ( R )‐3‐hydroxybutyryl, and acetimidoyl groups. They are most characteristics of O‐chains of Pseudomonas aeruginosa lipopolysaccharides, composed almost exclusively of amino sugars or amphoteric amino sugars; the latter seem to play an important role as serological determinants. The identification of these sugars and the structural determination of the O‐specific polysaccharides provide the chemical basis for the classification of P. aeruginosa strains. Some of the new monosaccharides enter also the polysaccharides from some other bacteria.