Open AccessThe use of poly (isobutyl cyanoacrylate) nanoparticles with selected antifungal drugs
Author(s) -
Bajwa P.S.,
Couvreur P.,
Volz P.A.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02323.x
Subject(s) - miconazole , amphotericin b , cyanoacrylate , candida albicans , drug , chemistry , antifungal , pharmacology , microbiology and biotechnology , antifungal drug , medicine , biology , organic chemistry , adhesive , layer (electronics)
The effect of degrading drug carrier poly (isobutyl cyanoacrylate) nanoparticles (NPs) on amphotericin B, 5‐fluorocytosine, and miconazole was studied by testing minimal inhibitory concentrations (MICs) of these drugs against Candida albicans with or without the presence of NPs. Amphotericin B was destroyed by degrading NPs, however, there was no effect on the other two drugs. The results caution the use of NPs as carriers for amphotericin B for treatment of mycotic infections.