Open AccessExpression of high affinity iron uptake systems by clinical isolates of Klebsiella
Author(s) -
Williams Paul,
Chart Henrik,
Griffiths Elwyn,
Stevenson Pauline
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02322.x
Subject(s) - aerobactin , enterobactin , siderophore , enterobacter aerogenes , klebsiella pneumoniae , microbiology and biotechnology , bacterial outer membrane , escherichia coli , biology , klebsiella , enterobacteriaceae , bacteria , chemistry , biochemistry , gene , genetics
Seventeen isolates of Klebsiella aerogenes, K. pneumoniae, K. oxytocum and K. edwardsii were examined for their ability to express iron‐regulated outer membrane proteins (IROMPs) and high affinity iron‐chelating agents (siderophores). In response to iron deprivation, all strains induced at least 4 IROMPs in the approximate M r range 70 000–85 000 and the phenolate siderophore enterobactin. Six strains also produced the hydroxamate siderophore aerobactin. The Klebsiella enterobactin receptor was identified as an 81 000 M r iron‐repressible outer membrane (OM) protein which appears to be highly conserved and shows considerable antigenic homology with that of Escherichia coli .