Open AccessInitiation of murein biosynthesis in Escherichia coli cells treated with β‐lactam antibiotics
Author(s) -
Pisabarro Antonio G.,
Portillo Francisco Garcia,
Rosa Enrique J.,
Pedro Miguel A.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02303.x
Subject(s) - penicillin , antibiotics , biosynthesis , lactam , peptidoglycan , biochemistry , cell wall , biology , penicillin binding proteins , cell , microbiology and biotechnology , chemistry , stereochemistry , enzyme
The study of the synthesis and accumulation of murein in cells initiating growth in the presence of β‐lactam antibiotics indicated: (i) Murein rearrangement contributes substantially to cell enlargement during the first doubling in cell mass; (ii) Penicillin‐binding protein 2 has the potential capability to synthesize most, if not all, the new murein required for the cells to double in mass.