Open AccessTemporary exposure to hydrogen peroxide increases intracellular protein degradation in E. coli
Author(s) -
Klemes Yoel,
Godinger Dina,
Aronovitch Jacob
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02282.x
Subject(s) - hydrogen peroxide , intracellular , proteolysis , chemistry , oxidative stress , escherichia coli , degradation (telecommunications) , protein degradation , biophysics , oxidative phosphorylation , biochemistry , microbiology and biotechnology , biology , enzyme , telecommunications , computer science , gene
A brief exposure of Escherichia coli cells to hydrogen peroxide doubled the rate of intracellular protein degradation. The enhanced protein degradation was energy‐dependent. The treatment with hydrogen peroxide caused a transient decrease in the cellular ATP level, but it seems unlikely that the increased rate of proteolysis was caused by starvation or by energy depletion. The findings suggest that a protective mechanism which prevents accumulation of damaged proteins in E. coli cells plays a role in cellular response to oxidative stress.