Open AccessA calmodulin inhibitor blocks morphogenesis in Candida albicans
Author(s) -
Roy B.Gupta,
Datta A.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02221.x
Subject(s) - trifluoperazine , germ tube , calmodulin , candida albicans , morphogenesis , phosphorylation , yeast , microbiology and biotechnology , biology , calcium , protein phosphorylation , biochemistry , corpus albicans , chemistry , protein kinase a , enzyme , gene , organic chemistry
A calmodulin inhibitor, trifluoperazine (TFP), can block yeast‐to‐germ‐tube morphogenesis of Candida albicans induced by N‐acetyl‐ d ‐glucosamine at 37°C. Furthermore, the ionophore A23187 can also block germ tube formation, which can be reversed by Ca 2+ . This indicates the possible involvement of calcium and calmodulin in morphogenesis of C. albicans . During germ tube formation, there is a progressive increase in the rate of protein phosphorylation, which is completely absent in non‐germinating cells (yeast form). Trifluoperazine can also inhibit this phosphorylation indicating that protein phosphorylation may also be involved in this process.