Open AccessEffect of iron on early changes in Escherichia coli ‐induced ascending pyelonephritis in rats
Author(s) -
Sharma S.,
Garg U.C.,
Ganguly N.K.,
Sharma B.K.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02214.x
Subject(s) - brush border , alkaline phosphatase , chemistry , escherichia coli , enzyme , medicine , biochemistry , proline , endocrinology , biology , amino acid , vesicle , membrane , gene
Uptake of d ‐glucose, l ‐lysine and l ‐proline and the kinetic parameters of alkaline phosphatase and γ‐glutamyl‐transpeptidase were evaluated in renal brush border membrane (BBM) vesicles prepared from control, pyelonephritic and iron‐administered pyelonephritic rats. The uptake of d ‐glucose and amino acids and V max of both the enzymes studied were found to be altered in pyelonephritic and iron‐administered pyelonephritic rats, but changes appeared earlier and more severely in iron‐administered infected animals than in other infected animals. These early physiological alterations were accompanied by higher bacterial colonisation in iron‐administered rats.