Open AccessInduction of the SOS response in Escherichia coli by 4‐quinolone antimicrobial agents
Author(s) -
Piddock Laura J.V.,
Wise Richard
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02213.x
Subject(s) - quinolone , escherichia coli , sos response , antimicrobial , microbiology and biotechnology , chemistry , enterobacteriaceae , antibiotics , biology , biochemistry , gene
The induction of the RecA protein in strains of Escherichia coli was demonstrated for five 4‐quinolone compounds. Using a recA :: lac fusion, the expression of the recA gene was quantified for each agent. Induction was shown to be time and concentration‐dependent. At a certain concentration (dependent on each 4‐quinolone) maximum induction was observed. Above this concentration, reduced induction was observed with an increase in 4‐quinolone concentration. The inducing concentration of each 4‐quinolone correlated well with the antibacterial activity of each agent.