Open AccessThe effects of traT insertion mutations on detergent sensitivity and serum resistance of Escherichia coli and Salmonella typhimurium
Author(s) -
Sukupolvi Soila,
O'Connor David,
Mäkelä P.Helena
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02102.x
Subject(s) - escherichia coli , mutant , salmonella , microbiology and biotechnology , enterobacteriaceae , mutation , gene , biology , bacteria , phenotype , insertion , wild type , chemistry , genetics
The SS‐A mutation of Salmonella typhimurium, which probably causes the production of a mutated TraT‐like protein, sensitizes the bacteria to hydrophobic antibiotics. A similar phenotype is caused by insertion mutations in the cloned traT gene of R6‐5. While the SS‐A mutants are resistant to detergents and have unaltered serum resistance, the insertion mutations sensitize both S. typhimurium and Escherichia coli to detergents and abolish the increase in serum resistance caused by the wild‐type traT gene product in E. coli .