Open AccessBinding characteristics of Escherichia coli type 1 fimbriae in the human kidney
Author(s) -
Virkola Ritva
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb02035.x
Subject(s) - fimbria , parenchyma , kidney , immunofluorescence , connective tissue , biology , escherichia coli , cytoplasm , chemistry , anatomy , biochemistry , endocrinology , immunology , antibody , botany , genetics , gene
Binding of the Escherichia coli type 1 fimbriae to frozen sections of human kidney was examined by indirect immunofluorescence. The purified fimbriae bound specifically to the luminal and cytoplasmic aspects of proximal tubules and to the connective tissue layer of veins and arteries. Distal tubules, collecting ducts, glomeruli and vascular endothelium were not stained by the fimbriae. The results do not support a role for type 1 fimbriae in invasion of E. coli into the renal parenchyma.