Open AccessFusidic acid resistance in Rhodococcus erythropolis due to an inducible extracellular inactivating enzyme
Author(s) -
Dabbs Eric R.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb01996.x
Subject(s) - fusidic acid , extracellular , enzyme , microbiology and biotechnology , rhodococcus , chemistry , biochemistry , bacteria , biology , staphylococcus aureus , genetics
Abstract Fusidic acid is a steroid antibiotic inhibiting Gram‐positive microorganisms. The mechanism of resistance previously characterised involves mutation alteration of the target moiety, protein synthesis elongation factor EFG. In the nocardioform bacterium Rhodococcus erythropolis, a novel resistance mechanism to this antibiotic was found, i.e., an inducible extracellular fusidic acid‐in‐activating enzyme. The presence of this enzyme increased roughly 30‐fold the antibiotic concentration at which the organism could grow.