Open AccessExperimental Vibrio cholerae wound infections
Author(s) -
Simpson Linda M.,
Dry Malinda A.,
Oliver James D.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb01988.x
Subject(s) - vibrio cholerae , microbiology and biotechnology , virulence , bacteremia , vibrionaceae , biology , bacteria , keratoconjunctivitis , cholera , antibiotics , virology , gene , genetics , biochemistry
The invasive potential of environmental and clinical strains of O1 and non‐O1 Vibrio cholerae was examined. Mice injected subcutaneously (s.c.) with strains of these organisms were monitored for the development of lesions or mortality. Of 12 strains of non‐O1 V. cholerae tested, 7 gave a high mortality rate. All other strains produced swelling and lesions at the site of inoculation. The injection of highly virulent strains of non‐O1 V. cholerae produced bacteremia. In contrast, only 1 of the 10 strains of O1 V. cholerae tested was highly lethal, and bacteremia was not detected. The highly virulent strains of O1 and non‐O1 V. cholerae failed to produce keratoconjunctivitis in the Sereny test. A qualitative enzyme study showed no differences in ability to produce enzymes associated with invasiveness.