Open AccessEffects of sinefungin and difluoromethylornithine on pathogenic free‐living amoebae in vitro
Author(s) -
Ferrante A.,
Abell T.J.,
Robinson B.,
Lederer E.
Publication year - 1987
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1987.tb01984.x
Subject(s) - naegleria fowleri , acanthamoeba , biology , in vitro , microbiology and biotechnology , ornithine decarboxylase , eflornithine , protozoa , biochemistry , enzyme , virology , meningoencephalitis
Naegleria fowleri and Acanthamoeba culbertsoni were found to be more susceptible to killing by the antifungal antibiotic, sinefungin, a known inhibitor of transmethylases, than by dl ‐α‐difluorome thylornithine (DFMO), a specific inhibitor of ornithine decarboxylase. In addition, the data showed that N. fowleri was far more susceptible to killing by sinefungin and DMFO than was A. culbertsoni .