Open AccessThe Anton blood group antigen is the erythrocyte receptor for Haemophilus influenzae
Author(s) -
Alphen Loek,
Poole Joyce,
Overbeeke Marijke
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01768.x
Subject(s) - haemophilus influenzae , agglutination (biology) , hemagglutination , microbiology and biotechnology , antigen , haemophilus , pasteurellaceae , sputum , bacteria , biology , latex fixation test , virology , immunology , antibody , medicine , antibiotics , pathology , tuberculosis , genetics
The first step in Haemophilus influenzae infections is the adherence of the bacteria to oropharyngeal epithelial cells. Those strains which adhere are also able to agglutinate human red cells. All adult erythrocyte samples were agglutinated by H. influenzae , but cord erythrocytes were negative. Subsequent testing of selected adult erythrocytes showed that the Anton antigen was essential for haemagglutination by H. influenzae from cerebrospinal fluid and sputum. This was shown by direct agglutination of Anton positive cells and inhibition studies using three anti‐Anton sera.