Open AccessAutogenous regulation by lysine of the lysA gene of Escherichia coli
Author(s) -
Martin Christine,
Borne Françoise,
Cami Brigitte,
Patte JeanClaude
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01676.x
Subject(s) - escherichia coli , effector , lysine , lac operon , gene , biology , enterobacteriaceae , gene product , fusion gene , fusion protein , chemistry , biochemistry , gene expression , amino acid , recombinant dna
The regulation of the synthesis of diaminopimelate decarboxylase (product of the lysA gene) of Escherichia coli was studied by measuring the expression of a lysA‐lacZ chromosomal fusion. It appeared to be under an autogenous regulatory control involving lysine as an effector. The LysA protein from Pseudomonas aeruginosa could replace the E. coli protein in its regulatory role, but with a lower efficiency.