Open AccessStimulation of peripheral lymphocytes from cancer patients and healthy subjects by Pseudomonas aeruginosa lectin
Author(s) -
GilboaGarber Nachama,
Avichezer Dodi,
Rozenszajn Leon Arie
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01411.x
Subject(s) - lectin , pseudomonas aeruginosa , immunocompetence , stimulation , concanavalin a , immunology , peripheral , microbiology and biotechnology , pseudomonadaceae , biology , cancer , medicine , bacteria , endocrinology , immune system , biochemistry , in vitro , genetics
The galactophilic lectin of the bacterium Pseudomonas aeruginosa (PA‐I) was used for mitogenic stimulation of peripheral bloodlymphocytes from cancer‐bearing patients and healthy subjects. This lectin, which preferentially stimulates sialidase‐treated lymphocytes, was shown to be useful in the detection of an impairment in the mitogenic response of the patients' lymphocytes. Its efficiency was at least as that of the Phaseolus vulgaris lectin (PHA), which is widely used for the diagnosis and prognosis of deficient immunocompetence states.