Open AccessPlasmid‐encoded resistance to acriflavine and quaternary ammonium compounds in methicillin‐resistant Staphylococcus aureus
Author(s) -
Gillespie M.T.,
May J.W.,
Skurray R.A.
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01346.x
Subject(s) - acriflavine , ethidium bromide , microbiology and biotechnology , plasmid , staphylococcus aureus , benzalkonium chloride , cetrimide , biology , plasmid preparation , chemistry , dna , bacteria , genetics , medicine , chlorhexidine , organic chemistry , dentistry , pbr322
The determinant for resistance to the antiseptics acriflavine, benzalkonium chloride and cetrimide and the intercalating dye, ethidium bromide has been physically mapped on pSK57, a penicillinase plasmid detected in strains of methicillin‐resistant Staphylococcus aureus . Restriction endonuclease analysis and DNA‐DNA hybridization indicate that this determinant is identical to that which encodes these resistances on the plasmid pSK1, which is the most frequently detected gentamicin resistance plasmid in methicillin‐resistant S. aureus isolates from Australian hospitals.