Open AccessInfluence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae
Author(s) -
Williams Paul,
Brown Michael R.W.
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01230.x
Subject(s) - haemophilus parainfluenzae , haemophilus influenzae , microbiology and biotechnology , bacterial outer membrane , haemophilus , biology , chemistry , bacteria , virology , escherichia coli , biochemistry , gene , genetics , antibiotics
Abstract The growth of both Haemophilus influenzae and H. parainfluenzae was progressively inhibited in media containing increasing concentrations of the iron chelator desferrioxamine. Iron restriction had little effect on the outer‐membrane (OM) protein profiles of type b or non‐typable H. influenzae although replacement of haemin with protoporphyrin IX resulted in the induction of an M r 73 000 protein in the type b strains. H. parainfluenzae , however, responded to iron restriction by inducing several new proteins in the range of M r 70 000 to 86 000.