Open AccessAlterations of the functional state of peritoneal macrophages during rat cytomegalovirus infection in vivo
Author(s) -
Hendrix M.G.R.,
Bruggeman C.A.,
Boven C.P.A.
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01222.x
Subject(s) - phagocytosis , peritoneum , in vivo , cytomegalovirus , staphylococcus aureus , microbiology and biotechnology , macrophage , immunology , chemiluminescence , chemistry , intraperitoneal injection , biology , in vitro , virus , herpesviridae , bacteria , pharmacology , biochemistry , viral disease , anatomy , genetics , organic chemistry
The effect of intraperitoneal (i.p.) infection with rat cytomegalovirus on the effector functions of peritoneal macrophages was investigated. There was an influx of polymorphonuclear leukocytes into the peritoneum on day 1 followed by an influx of macrophages on day 4. The macrophages harvested on day 4 showed enhanced levels of chemiluminescence emitted during phagocytosis of zymozan particles, and enhanced capacity to kill Staphylococcus aureus . Thereafter, the chemiluminescence level and the bactericidal capacity decreased, remaining low up to 6 months post‐infection. In addition, macrophages harvested from animals on day 7 showed increased phagocytosis of sheep red blood cells.