Open AccessPurification and properties of toxins A and B of Clostridium difficile
Author(s) -
Lyerly David M.,
Roberts Mary D.,
Phelps Carol J.,
Wilkins Tracy D.
Publication year - 1986
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1986.tb01206.x
Subject(s) - clostridium difficile , isoelectric point , microbiology and biotechnology , clostridiaceae , clostridium , peptide , isoelectric focusing , biology , chemistry , oxidizing agent , biochemistry , toxin , bacteria , antibiotics , genetics , organic chemistry , enzyme
Toxins A and B of Clostridium difficile were purified to homogeneity and some of their properties were examined. The toxins have similar LD 100 values in mice, share some similarities in their amino acid composition, and are both sensitive to oxidizing agents. However, they have different isoelectric points and do not show any significant peptide homology.