Open AccessEffect of Escherichia coli heat‐stable enterotoxin (ST) on calcium uptake by rat intestinal Brush‐Border Membrane Vesicles (BBMV)
Author(s) -
Ganguly Uma,
Talukder Subesh
Publication year - 1985
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1985.tb01606.x
Subject(s) - calcium , heat stable enterotoxin , brush border , enterotoxin , vesicle , escherichia coli , ionophore , chemistry , biochemistry , stimulation , biology , membrane , endocrinology , gene , organic chemistry
A partially purified Escherichia coli heat‐stable (ST) enterotoxin had been shown to increase the 45 Ca 2+ uptake by rat intestinal brush‐border membrane vesicles (BBMV). The effect of ST enterotoxin on calcium uptake by BBMV was significant compared with the control and was also dose‐dependent. The stimulation of calcium uptake by ST enterotoxin was inhibited by chemical agents which block the calcium entry into the cell. These data indicate that the ST acts as calcium ionophore in this particular system.