Open AccessNitrogen regulation of erythromycin formation in Streptomyces erythreus
Author(s) -
Flores Ma.Elena,
Sánchez Sergio
Publication year - 1985
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1985.tb01589.x
Subject(s) - erythromycin , ammonium , streptomyces , chemistry , nitrogen , antibiotics , streptomycetaceae , microbiology and biotechnology , biochemistry , actinomycetales , bacteria , biology , organic chemistry , genetics
Erythromycin formation decreased in Streptomyces erythreus as a function of the ammonium concentration present in the medium. Total inhibition of synthesis was obtained with 100 mM NH 4 Cl but medium pH and culture growth were not significantly affected. A similar effect was obtained with NH 4 NO 3 or (NH 4 ) 2 SO 4 indicating that ammonium ion probably repressed formation of antibiotic.