Open AccessLong‐term persistence of scrapie infection in mouse spleens in the absence of clinical disease
Author(s) -
Collis S.C.,
Kimberlin R.H.
Publication year - 1985
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1985.tb00844.x
Subject(s) - scrapie , spleen , persistence (discontinuity) , intraperitoneal injection , biology , disease , virology , strain (injury) , clinical disease , incubation period , mouse strain , pathology , immunology , medicine , incubation , anatomy , prion protein , endocrinology , geotechnical engineering , engineering , biochemistry , gene
Studies were made of the 87V strain of scrapie in IM mice ( Sinc p7 ) to discover why the intracerebral route of injection of a 1% brain inoculum produced clinical scrapie but the intraperitoneal route did not. It was found that the intraperitoneal route rapidly established a persistent infection in spleen (and presumably other extraneural tissues) without there being any significant spread of infection to the brain during the 1.5 year period of observation.