Open AccessEffect of Fusobacterium necrophorum haemolysin on peripheral leukocytes in vitro
Author(s) -
Kanoe Masamitsu,
Iriki Makoto
Publication year - 1985
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1985.tb00789.x
Subject(s) - fusobacterium necrophorum , hemolysin , microbiology and biotechnology , in vitro , antiserum , bacteroidaceae , cytotoxic t cell , biology , chemistry , bacteria , immunology , antibody , virulence , biochemistry , gene , genetics
Fusobacterium necrophorum haemolysin was cytotoxic for animal leukocytes. The most sensitive cells to the haemolysin were rabbit leukocytes, of which disruption of the cells and protoplastic extrusion were induced. The response was dose‐ and time‐dependent, and was neutralised by antiserum. Scanning electron microscopy revealed that the haemolysin induced destruction of rabbit leukocytes, leaving membrane fragments.