Open AccessSuppression of cyclic AMP‐induced cell excitation in Dictyostelium discoideum by inhibitors of eicosanoid oxidation
Author(s) -
Sampson Jeffrey,
Town Christopher D.
Publication year - 1985
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1985.tb00669.x
Subject(s) - chemotaxis , dictyostelium discoideum , dictyostelium , microbiology and biotechnology , stimulus (psychology) , excitatory postsynaptic potential , eicosanoid , receptor , stimulation , biology , chemistry , biochemistry , neuroscience , enzyme , arachidonic acid , psychology , psychotherapist , gene
Receptor‐mediated stimulation of Dictyostelium cells by the aggregative chemoattractant cyclic AMP leads to a complex excitatory response resulting in chemotaxis and the synthesis and release of cyclic AMP as the relayed chemotactic signal. However, the mechanism of this stimulus‐response coupling is not well understood. In this study, we show that a number of compounds, best known as inhibitors of cyclooxygenase activity in mammalian cells, prevent cyclic AMP receptor‐mediated cell excitation and cyclic AMP accumulation in aggregation‐competent Dictyostelium cells. These observations suggest that some eicosanoid‐like compound(s) may be involved in stimulus‐response coupling in this organism, as is the case in higher eukaryotic cells.