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Characterization of penicillin‐resistant Streptococcus faecium mutants
Author(s) -
Fontana Roberta,
Bertoloni Giulio,
Amalfitano Guido,
Canepari Pietro
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01368.x
Subject(s) - autolysis (biology) , penicillin , mutant , overproduction , microbiology and biotechnology , minimum inhibitory concentration , penicillin binding proteins , antibiotics , chemistry , streptococcus , bacteria , biology , biochemistry , genetics , gene , enzyme
The characteristics of three spontaneous mutants of Streptococcus faecium PS which overproduce the penicillin‐binding protein (PBP) 5 and are resistant to penicillin were investigated and compared with those of the parent. The mutants grew a little more slowly than the parent, had a smaller cellular size, did not grow as filaments in the presence of penicillin minimal inhibitory concentration (MIC), and were significantly more prone to autolysis. The relationship between the characteristics of the mutants and the overproduction of PBP 5 is discussed.

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