Open AccessInhibition of growth and development of Serpula lacrimans by the non‐metabolised amino acid analogue α‐aminoisobutyric acid *
Author(s) -
Watkinson S.C.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01313.x
Subject(s) - aminoisobutyric acid , metabolism , amino acid , mycelium , glutamic acid , biochemistry , chemistry , biology , botany
Mycelium of Serpula lacrimans accumulated 14 C‐labelled α‐aminoisobutyric acid (AIB) against a concentration gradient but did not metabolise it, or incorporate it into protein. Uptake of glutamic acid was inhibited in the presence of AIB to an extent proportional to the logarithm of its concentration. Translocation of AIB occurred in the mycelium over a distance of 11 cm. These results suggest that the mechanism of the previously observed inhibition by AIB of extension growth and wood decay in S. lacrimans depends on the ability of this non‐metabolised amino acid to exclude utilisable amino acids from uptake systems and metabolism, thus inducing nitrogen starvation.