Open AccessMultiple sites of inhibition of mitochondrial electron transport by chloramphenicol in Neurospora crassa
Author(s) -
Schwitzguébel JeanPaul,
Palmer John M.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01250.x
Subject(s) - neurospora crassa , chloramphenicol , electron transport chain , neurospora , rotenone , biology , alternative oxidase , respiratory chain , biochemistry , mitochondrion , nadh dehydrogenase , oxidase test , enzyme , mitochondrial dna , antibiotics , gene , mutant
The effects in vitro of chloramphenicol on the mitochondrial electron transport of Neurospora crassa were investigated under phosphorylating, non‐phosphorylating and uncoupled conditions. The antibiotic acted at more than one site of the respiratory chain: exogenous NADH dehydrogenase, Complex I, the rotenone‐resistant by‐pass and the alternative oxidase, although an unspecific effect could not be totally excluded.