Open AccessInability of men mutants of Escherichia coli to use trimethylamine‐ N ‐oxide as an electron acceptor
Author(s) -
Meganathan R.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01244.x
Subject(s) - trimethylamine n oxide , trimethylamine , mutant , electron acceptor , chemistry , escherichia coli , biosynthesis , biochemistry , oxide , biology , enzyme , organic chemistry , gene
Mutants of Escherichia coli blocked in the biosynthesis of menaquinone were unable to use trimethylamine‐ N ‐oxide as an electron acceptor in complex medium containing glucose. Trimethylamine‐ N ‐oxide reduction and the consequent in‐crease in growth could be restored in a menC mutant by either o ‐succinylbenzoic acid (OSB) or 1,4‐dihydroxy‐2‐naphthoic acid (DHNA). In the case of a menB mutant, growth could not be restored by OSB; but addition of DHNA resulted in the restoration of growth to the full extent. These results are consistent with the metabolic blocks in the respective men mutants.