Open AccessTrimethoprim, failure to penetrate into Pseudomonas aeruginosa cells
Author(s) -
Werner R.G.,
Goeth H.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01063.x
Subject(s) - pseudomonas aeruginosa , mutant , escherichia coli , trimethoprim , microbiology and biotechnology , wild type , chemistry , pseudomonas , enzyme , pseudomonadaceae , pseudomonadales , bacteria , biology , biochemistry , antibiotics , gene , genetics
Permeability mutants of Escherichia coli and Pseudomonas aeruginosa demonstrated a significantly higher susceptibility for trimethoprim (TMP). Although the target enzyme of this drug, dihydrofolic acid reductase, expressed about the same activity, it was comparably inhibited by TMP in permeability mutants and in wild‐type strains. The weak activity in wild‐type strains depends on the decreased uptake.