Open AccessPossible role of cAMP in the synthesis of β‐glucanases and β‐xylanases of Bacillus circulans WL‐12
Author(s) -
Esteban R.,
Nebreda A.R.,
Villanueva J.R.,
Villa* T.G.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb01041.x
Subject(s) - bacillus circulans , biochemistry , xylanase , enzyme , inducer , xylan , effector , nucleotide , bacillus (shape) , chemistry , biology , microbiology and biotechnology , gene
Bacillus circulans WL‐12 secretes 1,4‐β‐ d ‐xylanase and 1,3‐β‐ d ‐ and 1,6‐β‐ d ‐glucanase activities. All of them are catabolites regulated by glucose and, while xylanase needs xylan as the inducer, the two latter enzyme activities are formed once glucose is depleted. Cyclic nucleotides such as adenosine 3′,5′‐monophosphate (cAMP) and guanosine 3′,5′ monophosphate (cGMP) exhibit a negative effect on enzyme synthesis if added to the culture media. Based on the fact that only cAMP is found in cells growing in glucose‐rich media we propose a model for B. circulans WL‐12 in which cAMP acts as a negative effector for regulating the synthesis of these enzymes. The model is not, however, extrapolated to other Bacillus species and all B. circulans strains.