Open AccessPolymyxin B nonapeptide sensitizes Escherichia coli to valinomycin and A23187 ionophores
Author(s) -
Alatossava T.,
Vaara M.,
Baschong W.
Publication year - 1984
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1984.tb00736.x
Subject(s) - valinomycin , escherichia coli , ionophore , polymyxin b , chemistry , polymyxin , intracellular , nigericin , biochemistry , microbiology and biotechnology , antibiotics , membrane potential , biology , membrane , gene
Treatment of Escherichia coli cells with polymyxin B nonapeptide (PMBN) makes them susceptible to valinomycin and A23187 action. The sensitivity of the cells towards these ionophores is enhanced at least 50‐ or 100‐fold, respectively. PMBN/ionophore treatment should make it possible to influence intracellular potassium (K) and magnesium (Mg) concentrations of E. coli in vivo.